NLRP3 inflammasome mechanism and therapeutic targets in diabetic cardiomyopathy
نویسندگان
چکیده
Diabetic cardiomyopathy (DCM) is a serious complication of diabetes caused by oxidative stress, inflammation, insulin resistance, myocardial fibrosis, and lipotoxicity; its nature insidious, complex difficult to treat. NLRP3 inflammasome triggers the maturation release pro-inflammatory cytokines, participates in pathophysiological processes such as resistance addition being closely related development progression diabetic cardiomyopathy. The inhibitors targeting specific aspects inflammation suggests that can be used treat This paper aims summarize mechanism therapeutic targets cardiomyopathy, provide new suggestions for treatment this disease.
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ژورنال
عنوان ژورنال: Gaceta Medica De Mexico
سال: 2023
ISSN: ['0016-3813', '2696-1288']
DOI: https://doi.org/10.24875/gmm.22000403